Edward K. Chow - Rancho Palos Verdes CA,
Genhong Cheng - Calabasas CA,
The Regents of the University of California - Oakland CA
514 44, 514630, 514 54, 514293, 514562
The invention provides compounds, compositions, animal models, drug screening methods, pharmaceutical compositions, and methods of treatment which relate to the modulation of the metabolism of xenobiotic compounds by administering agents which act on IRF3 or an IRF3 control pathway to modulate the activity, expression, or levels of cytochrome P450 enzymes involved in the metabolism of xenobiotic compounds in a subject.